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丁蓓-如意体育app下载
 
师资队伍

丁蓓教授

电子邮件:bei.ding@sjtu.edu.cn;课题组网站:https://www.x-mol.com/groups/bei_ding/

  • 教育背景

    2005-2009:北京大学化学与分子工程学院 ,化学,学士

    2009-2014:美国密西根大学,电气工程(光学方向),硕士; 物理化学,博士


  • 工作经历

    2014-2017:美国宾夕法尼亚大学,博士后

    2017.9-2023.12: 如意体育app下载长聘教轨副教授、超快科学中心PI

    2023.12-至今:如意体育app下载长聘副教授

    2024.12-至今:如意体育app下载教授、张江高等研究院双聘教授



  • 研究方向

    1)  天然和人工光酶光受体的反应驱动力学和结构驱动力学机制

    含黄素辅基的蛋白质在自然界有广泛的分布并展现了多样的功能。课题组结合分子生物学和超快光谱学手段研究此类蛋白的分子机理。目前课题组开展的课题包括:1. 解析蓝光光受体蛋白BLUF域的光化学和异构化过程,理解其生物功能。2. 结合非平衡态电子转移理论,研究黄素氧化还原蛋白的光致电子转移过程。3. 解析光解酶光致还原机理和修复损伤DNA机理。

    2) 围绕光生物体系动态机制发展混合飞秒脉冲中红外光谱技术

    结合TRIR、2DIR和t-2DIR的可拓展光路,可进一步开发为其他脉冲技术高阶光谱。


  • 科研项目

    在研:

    科技部重点研发计划青年项目首席

    国家自然科学基金面上项目

    国家自然科学基金重大研究计划培育项目


    已结题:

    国家自然科学基金青年项目(2020-2022)

    国家自然科学基金面上项目(2020-2023)

    上海科委“扬帆计划”项目(2017-2020)

    上海教委“晨光计划”项目(2017-2020)

  • 代表性论文专著

    2025

    33. Wang, B.#, Dong, Y.#, Zhao, Z.#, Zhou, Z., Kang, X.-W., Li, Y., Ding, B.* Distinct Fermi Resonance Patterns of Weak Coupling in 2D-IR Spectra of 5-Cyanoindole Revealed by Isotope Labeling. J. Phys. Chem. B 2025129, 1036


    32. Zhou, Z.#, Chen, Z.#, Kang, X.-W.#, Ding, B.*, Zou, S., Tang, S., Zhou, Y., Wang, B., Zhong, D.* Elucidation of a Distinct Photoreduction Pathway in Class II Arabidopsis Thaliana Photolyase. Proc. Natl. Acad. Sci. U.S.A. 2025122, e2416284121


    2024

    31. Zhou, Y.#, Kang, X.-W.#, Zhou, Z., Chen, Z., Zou, S., Tang, S., Wang, B., Wang, K., Zhong, D.*, Ding, B.*. Unified Mechanism of Light-State BLUF Domain Photocycles by Capturing Proton Relay Intermediates. Ultrafast Sci. 2024, 4, 0072. (Cover paper) 


    30. Xu, W.*#, Mou, K.#, Lu, Z.#, Kang, X.-W., Guo, Y., Ding, B., Chen, Z., Wang, Z.*, Wu, Q.*, Catalytic Promiscuity of Fatty Acid Photodecarboxylase Enables Stereoselective Synthesis of Chiral α-Tetralones, Angew. Chem. Int. Ed. 2024, e202412862. 


    29. Kang, X.-W., Wang, K., Zhang, X., Zhong, D.*, Ding, B.*Elementary Reactions in the Functional Triads of the Blue-Light Photoreceptor BLUF Domain. J. Phys. Chem. B 2024128, 2065 (Invited Perspective, ACS Editor’s Choice, Cover paper)


    28. Zhou, Y.#, Tang, S.#, Chen, Z., Zhou, Z., Huang, J., Kang, X.-W., Zou, S., Wang, B., Zhang, T., Ding, B.*, Zhong, D.*, Origin of the Multi-phasic Quenching Dynamics in the BLUF domains Across the Species. Nat. Commun., 202415, 623. 


    27. Shi, Q., Kang, X.-W., Liu, Z., Sakthivel, P., Aman, H., Chang, R., Yan, X., Pang, Y., Dai, S.*, Ding, B.*Ye, J.*, Single-Electron Oxidation-Initiated Enantioselective Hydrosulfonylation of Olefins Enabled by Photoenzymatic Catalysis, J. Am. Chem. Soc.2024146, 2748. (Highly cited paper)


    26. Wang, B.#, Zhou, Z.#, Zhang, Q., Dong, B., Kang, X.-W., Ding, B.*, Elucidating State-Specific Dynamics of 1La and 1Lb in Cyanoindole Derivatives Using UV/Vis Pump IR Detection. Chem. Phys.2024, 576, 112095.


    2023

    25. Zhang, Q., Zhou, Z., Deng, B., Wang, B., Kang, X.-W., Chen, J., Ding, B.*, Zhong, D.*, An Ultrafast Phototrigger of the Trp5CN–Trp Motif in a β-Hairpin Peptide. J. Chem. Phys.2023158, 201102. 

     

    24. Hu, R., Zhou, Y., Lin, L., Ding, B.*, Lu, Q.*, Structure of the BLUF Protein TePixD Y8F Mutant. Progress in Biochemistry and Biophysics2023.

     

    23. Chen, Z.#, Kang, X.-W.#, Zhou, Z., Zhou, Y., Tang, S., Zou, S., Wang, K., Huang, J., Ding, B.*, Zhong, D.*, Dissecting the Ultrafast Stepwise Bidirectional Proton Relay in a Blue-Light Photoreceptor. J. Am. Chem. Soc.2023145, 3394. 

     

    2022

    22. Zhou, Z.#; Chen, Z.#; Kang, X.-W.; Zhou, Y.; Wang, B.; Tang, S.; Zou, S.; Zhang, Y.; Hu, Q.; Bai, F.Ding, B.* and Zhong, D.*, The Nature of Proton-Coupled Electron Transfer in a Blue Light Using Flavin Domain. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2203996119.

     

    21. Kang, X.-W.#, Chen, Z.#, Zhou, Z., Zhou, Y., Tang, S., Zhang, Y., Zhang, T., Ding, B.* and Zhong, D.*, Direct Observation of Ultrafast Proton Rocking in the BLUF Domain. Angew. Chem. Int. Ed. 2022, 61, e202114423.  (Frontispiece and Hot Paper)


    20. Yang, J., Zhang, Y., He, T.F., Lu, Y., Wang, L., Ding, B.* and Zhong, D.*, Ultrafast Nonequilibrium Dynamics of Short-range Protein Electron Transfer in Flavodoxin. Phys. Chem. Chem. Phys. 2022, 24, 382-391. 

     

    19. Wang, S., Zhou, Q., Li, Y., Wei, B., Liu, X., Zhao, J., Ye, F., Zhou, Z., Ding, B. and Wang, P.*, Quinoline-Based Photolabile Protection Strategy Facilitates Efficient Protein Assembly. J. Am. Chem. Soc. 2022, 144, 3, 1232–1242. 

     

    2021
    18. Zhang, Q., Wang, B., Zhang, Y., Yang, J., Deng, B., Ding, B.* and Zhong, D.*, 2021. Probing Intermolecular Interactions of Amyloidogenic Fragments of SOD1 by Site-Specific Tryptophan and Its Noncanonical Derivative.     J. Phys. Chem. B 2021, 125, 48, 13088-13098. 

     

    Before Joining Shanghai Jiao Tong University

    17. Patel, H.#Ding, B.#, Ernst, K., Shen, L., Yuan, W., Tang, J., Drake, L.R., Kang, J., Li, Y., Chen, Z. and Schwendeman, A.* Characterization of apolipoprotein AI peptide phospholipid interaction and its effect on HDL nanodisc assembly. Int. J. Nanomedicine201914, 3069. (#co-first author)

     

    16. Ding, B.; Yang, L.; Mukherjee, D.; Chen, J.; Gao, Y.*; Gai, F.* Microscopic Insight into the Protein Denaturation Action of Urea and Its Methyl Derivatives. J. Phys. Chem. Lett. 20189, 1–12.

     

    15. Hilaire, M. R.#Ding, B.#; Mukherjee, D.#; Chen, J.; Gai, F.* Possible Existence of α-Sheets in the Amyloid Fibrils Formed by a TTR 105–115 Mutant. J. Am. Chem. Soc. 2018140 (2), 629–635. (#co-first author)

     

    14. Ding, B.; Mukherjee, D.; Chen, J.; Gai, F.* Do Guanidinium and Tetrapropylammonium Ions Specifically Interact with Aromatic Amino Acid Sidechains?  Proc. Natl. Acad. Sci. U.S.A.  2017114, 1003-1008

     

    13. Ding, B.; Hilaire, M. R.; Gai, F.* Infrared and Fluorescence Assessment of Protein Folding and Functional Dynamics. J. Phys. Chem. B (Feature Article), 2016120, 5103-5113

     

    12. Ding, B.; Jasensky, J.; Li, Y.; Chen, Z.* Engineering and Characterization of Peptides and Proteins at Surfaces and Interfaces: A Case Study in Surface-Sensitive Vibrational Spectroscopy. Acc. Chem. Res. 201649, 1149-1157.

     

    11. Ding, B.; Panahi, A.; Ho, J. J.; Laaser, J. E.; Brooks, C. L.; Zanni, M. T.*; Chen, Z.* Probing Site-Specific Structural Information of Peptides at Model Membrane Interface in SituJ. Am. Chem. Soc. 2015137, 10190-10198.

     

    10. Ding, B.; Tesmer, J.; Chen, Z.* Unveiling the Membrane-Binding Properties of N-terminal and C-terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies. Langmuir 201330, 823-831

     

    9. Ding, B.; Laaser J. E.; Liu Y.; Wang P.; Zanni M. T.*, Chen, Z.* Site-specific Orientation Determination of an α-helical Peptide Ovispirin-1 from Isotope labeled Sum Frequency Generation. J. Phys. Chem. B 2013117, 14625-14634

     

    8. Ding, B.; Soblosky L., Nuygen, K.; Geng J.; Yu X.; Ramamoorthy A.; Chen, Z.* Physiologically-Relevant Modes of Membrane Interactions by the Human Antimicrobial Peptide, LL-37, Revealed by SFG Experiments. Sci. Rep. 20133, 1854

     

    7. Ding, B.; Chen, Z.* Molecular Interactions between a Cell Penetrating Peptide Pep-1 and Model Cell Membranes. J. Phys. Chem. B 2012116, 2545-2552

     

    6. Ding, B.; Washington, V.; Dunietz, B. D.* On the Conditions for Enhanced Transport Through Molecular Junctions Based on Metal Centers Ligated by Pyridazino-derived Ligands. Mol. Phys. 2010108, 2591-2599

     

    5. Boughton, A.; Yang, P.; Tesmer, V.; Ding, B.Tesmer, J.*Chen, Z.* Heterotrimeric G protein β1γ2 Subunits Change Orientation Upon Complex Formation with G protein-Coupled Receptor Kinase 2 (GRK2) on a Model Membrane. Proc. Natl. Acad. SciU.S.A. 2011108, E667-E673

     

    4. Zhang, C.*; Wang, J.; Ding, B.; Jasensky, J. Quantitative Spectral Analysis of Coherent Anti-Stokes Raman Scattering Signals: C-H Stretching Modes of the Methyl Group. J. Phys. Chem. B 2014118, 7647-7656

     

    3. Zhang, C.*Wang, J.; Khmaladze, A.; Liu, Y.; Ding, B.Jasensky, J.; Chen, Z. Examining Surface and Bulk Structures Using Combined Nonlinear Vibrational Spectroscopies. Opt. Lett. 201136, 2272-2274

     

    2. Chen, Z. Q.; Ding, F.; Hao, F.; Guan, M.; Bian, Z. Q.*Ding, B.; Chen, F. F.; Huang C. H. Synthesis and Electroluminescent Property of Novel Europium Complexes with Oxadiazole Substituted 1,10-phenanthroline and 2,2 '-bipyridine LigandsNew. J. Chem. 201034, 487-494.

     

    1. Chen, Z. Q.; Ding, F.; Hao, F.; Bian, Z. Q.*; Ding, B.; Zhu, Y. Z.; Chen, F. F.; Huang C. H.* Highly Efficient OLED based on  Terbium ComplexesOrg. Electron. 200910, 939-494. 


  • 荣誉奖励

    2013年 美国密西根大学Barbour Scholarship

    2012年 美国密西根大学Rackham International Research Fellowship

    2008年 北京大学莙政学者

  • 人才需求

    课题组有以下职位敞开:

    一、博士后

    要求:对本组科研方向有一定兴趣,有物理化学、结构生物学、生物化学、光学博士学位的优先。请将个人简历发至PI邮箱。

    待遇:按照如意体育app下载博士后待遇标准从高发放。

     

    二、博士生和硕士生

    要求:本组从事学科交叉研究,科研氛围浓厚,但要学的东西多,出活慢。需要申请者对科研本身充满激情。有意请将个人简历和成绩单发到PI邮箱询问是否有名额。正式确定接收之前会邀请来实验室参观交流。

     

    三、科研助理

    需要有本科或硕士学历。要求认真负责,对科研工作有一定兴趣。

    待遇:按照如意体育app下载科研助理待遇标准从高发放。

     

    四、本科生

    要求:对科研本身充满好奇,愿意探索自己的感兴趣的方向,欢迎交大化学、物理、生物、计算机等专业的本科生加入。

     

    本组的本科生项目一览:

    张小凡:致远学者计划 在研

    刘冬锐:致远学者计划 结题

    邓博丹、董博:致远学者计划 结题

    黄久龙、任若彤、王楷霖:大创计划 结题

    唐思危:莙政学者计划 结题

    黄久龙:PRP 结题

    张天一:大创计划 结题

    李欣然、李润晗:PRP 结题

    董博、邓博丹:PRP 结题 出色

    唐思危、潘璐颖:PRP 结题


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E-mail:sjtuscce@sjtu.edu.cn

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