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袁乾家-如意体育app下载
 
师资队伍

袁乾家长聘(教轨)副教授

电子邮件:yuanqianjia@sjtu.edu.cn
通讯地址:上海市东川路800号化学B楼413室
个人主页: http://wanbin.sjtu.edu.cn

  • 教育背景

    2011.09~2015.10    博士    应用化学                 如意体育app下载(导师: 张万斌 院士)

    2008.09~2011.07    硕士    制药工程与技术     华东理工大学(导师: 曾步兵 教授)

    2004.09~2008.07    学士    制药工程与技术     贵州大学

  • 工作经历

    2020.05~至今         长聘(教轨)副教授       如意体育app下载

    2017.04~2019.07    博士后                               美国犹他大学(协作导师: Prof. Matthew S. Sigman)

    2015.11~2020.04    师资博士后                       如意体育app下载(协作导师: 颜德岳 院士 和 张万斌 院士)



  • 研究方向

    烯烃和酮的高值转化

    重大需求药物或关键中间体的高效绿色制备

  • 代表性论文专著

    Haipeng Wei, Yicong Luo, Jinbao Ren, Qianjia Yuan*, and Wanbin Zhang*. Ni(II)-Catalyzed Asymmetric Alkenylation and Arylation of Aryl Ketones with Organoborons via 1,5-Metalate Shift. NatCommun202415,  8775.

    Zhengdong Ding, Yicong Luo, Qianjia Yuan, Guangjie Wang, Zhenpeng Yu, Min Zhao, Delong Liu, and Wanbin Zhang*. Ru-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated γ-Lactams. J. Am. Chem. Soc. 2024146, 25312-25320.(应用于抗癫痫药物--布瓦西坦制备工艺)

    Tierui Pan, Qianjia Yuan*, Defeng Xu*, and Wanbin Zhang*. Iridium-Catalyzed Asymmetric Hydrogenation of Unfunctionalized Cycloalkenes to Access Chiral 2-Aryl Tetralins.  Org. Lett. 202426, 5850-5855. (应用于治疗晚期乳腺癌药物--艾拉司群制备工艺)

    Mo Wang, Lu Zhang, Xiaohong Huo, Zhenfeng Zhang, Qianjia Yuan, Panpan Li, Jianzhong Chen, Yashi Zou, Zhengxing Wu, and Wanbin Zhang*. Catalytic Asymmetric Synthesis of the Anti-COVID-19 Drug Remdesivir.  Angew. Chem. Int. Ed. 202059, 20814-20819. (VIP)(应用于抗新冠药物--瑞德西韦制备工艺)

    Fei Li, Yicong Luo, Jinbao Ren, Qianjia Yuan*, Deyue Yan, and Wanbin Zhang*. Iridium-Catalyzed Remote Site-Switchable Hydroarylation of Alkenes Controlled by Ligands. Angew. Chem. Int. Ed. 202362, e202309859. (Hot Paper)

    Tao Song, Yicong Luo, Kuiyang Wang, Bingyi Wang, Qianjia Yuan*, and Wanbin Zhang*. Nickel-Catalyzed Remote C(sp3)-N/O Bond Formation of Alkenes with Unactivated Amines and Alcohols. ACS Catal202313, 4409-4420.

    Qianjia Yuan, and Matthew S. Sigman*. Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams. J. Am. Chem. Soc. 2018140, 6527-6530.

    Jianbo Liu, Qianjia Yuan, F. Dean Toste, and Matthew S. Sigman*. Enantioselective Construction of Remote Tertiary Carbon-Fluorine Bonds. Nat. Chem. 201911, 710-715.

    Fei Li, Yicong Luo, Jinbao Ren, Qianjia Yuan*, Deyue Yan, and Wanbin Zhang*. Iridium-Catalyzed Asymmetric Hydroarylation of Unactivated Alkenes with Heterobiaryls: Simultaneous Construction of Axial and Central Chirality. Org. Lett. 2024, 26, 6835-6840.

    Fei Li, Jinbao Ren, Yifan Song, Qianjia Yuan*, Deyue Yan, and Wanbin Zhang*. Iridium-Catalyzed 1,3-Rearrangement of Allylic Ethers. OrgLett202325, 8727–8732.

    Tao Song, Kuiyang Wang, Qianjia Yuan*, and Wanbin Zhang*. Nickel-Catalyzed Hydroamination and Hydroalkoxylation of Enelactams with Unactivated Amines and Alcohols.  Org. Lett. 202325, 6093-6098.

    Yu Nie#, Qianjia Yuan#, and Wanbin Zhang*. Axis-Unfixed Biphenylphosphine-Oxazoline Ligands: Design and Applications in Asymmetric Catalytic Reactions. ChemRec202323, e202300133. (Invited Account; #co-first author)

     Zhengdong Ding, Feng Gao, Yining Lu, Qianjia Yuan*, Wei-Ping Deng*, and Wanbin Zhang*. Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones: Access to Chiral 2-Substituted Cyclopentyl Aryl Ketones. PrecisChem20231, 146-152. (Invited paper)

    Fei Li, Yicong Luo, Xuejie Zhu, Yong Ye, Qianjia Yuan*, and Wanbin Zhang*. Iridium-Catalyzed 1,3-Rearrangement of Allylic Alcohols. Chem. Eur. J. 202329, e202300027.

    Yu Nie, Jing Li, Qianjia Yuan*, and Wanbin Zhang*. Synthesis of Chiral Hydantoins and Thiazolidinediones via Iridium-Catalyzed Asymmetric Hydrogenation. Chin. J. Chem. 202240, 819-824.

    Yu Nie, Qianjia Yuan, Feng Gao, Masahiro Terada, and Wanbin Zhang*. Iridium-Catalyzed Double Asymmetric Hydrogenation of 2,5-Dialkylienecyclopentanones for the Synthesis of Chiral Cyclopentanones.  Org. Lett. 2022, 24, 7878-7882.

    Yu Nie, Jing Li, Jun Yan, Qianjia Yuan*, and Wanbin Zhang*. Synthesis of Chiral 2-Substituted 1,4-Benzoxazin-3-ones via Iridium-Catalyzed Enantioselective Hydrogenation of Benzoxazinones. Org. Lett. 202123, 5373-5377.

    Chenghao Ye, Feng Gao, Haipeng Wei, Jianzhong Chen, Guoqiang Yang, Qianjia Yuan*, and Wanbin Zhang*. Pd(II)-Catalyzed Enantioselective Ring-Contraction for the Construction of 1,4-Benzoxazines. J. Org. Chem. 202186, 16573-16581.

    Qianjia Yuan#, Matthew B. Prater#, and Matthew S. Sigman*. Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy. Adv. Synth. Catal. 2020362, 326-330. (Special issue honoring Eric Jacobsen on his 60th birthday). (#co-first author)

    Qianjia Yuan, and Matthew S. Sigman*. Palladium-Catalyzed Enantioselective Alkenylation of Enelactams using a Relay Heck Strategy. Chem. Eur. J. 201925, 10823-10827.

    Nicholas J. Race#, Qianjia Yuan#, and Matthew S. Sigman*. Enantioselective C2-Alkylation of Indoles through a Redox-Relay Heck Reaction of 2-Indole Triflates. Chem. Eur. J. 201925, 512-515. (#co-first author)

    Kun Yao, Qianjia Yuan, Xingxin Qu, Yangang Liu, Delong Liu*, and Wanbin Zhang*. Pd-Catalyzed Asymmetric Allylic Substitution Cascade Using α-(Pyrdin-1-yl)-acetamides Formed in situ as Nucleophiles. Chem. Sci. 201910, 1767-1772. 

    Qianjia Yuan, Delong Liu*, and Wanbin Zhang*. Synthesis of Chiral γ-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic γ-Hydroxy γ-Lactams. Org. Lett. 201719, 1886-1889. 

    Qianjia Yuan, Delong Liu*, and Wanbin Zhang*. Iridium-Catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated γ-Lactams: Scope and Mechanistic Studies. Org. Lett. 201719, 1144-1147.

    Qianjia Yuan, and Wanbin Zhang*. Applications of Phosphoramidite Ligands in Ir-Catalyzed Asymmetric Hydrogenation Reactions. Chin. J. Org. Chem. 201636, 274-282.

    Qianjia Yuan, Kun Yao, Delong Liu, and Wanbin Zhang*. Iridium-Catalyzed Allyl-Allyl Cross-Coupling of Allylic Carbonates with (E)-1,3-Diarylpropenes. Chem. Commun. 201551, 11834-11836.

  • 软件版权登记及专利

    CN201210181561.7;CN201310100684.8;CN201310098445.3;CN201310100682.9;CN201310100681.4;CN201310100675.9;WO2013181913;CN102199186B;CN102295679B;CN101973905A;CN117362142A;CN202010495819;CN202010495820;CN116603570A;PCT/CN2023/082161;CN202210736574.X;CN202210736573.5.


  • 荣誉奖励

    国家自然科学奖二等奖(5/5)

    "青蒿素的高效合成" 入选2012年国内十大科技新闻

    "青蒿素的高效合成" 入选2012年上海市十大科技成果

    上海市产学研协作出色项目奖特等奖(2/10)

    上海市浦江(A类)人才计划

    上海市普通高等学校出色毕业生

    博士研究生国家奖学金

  • 教学工作

    研究生:《高等有机化学》
    本科生:《有机化学》《有机化学实验》

地址:上海市东川路800号 200240
电话:021-54742893
E-mail:sjtuscce@sjtu.edu.cn

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